I have contemplated the same move - I have a 2020 2500RL. I just measured my clearance with the original westlakes and it seems to be about 3.75". I installed the CRE3000 last year and I don't remember how much that affected the clearance (seem to remember overall height of maybe .75" or so. The Morryde qualification guide says they want 3" clearance between the tire and the top of the wheel well, so in my case it seems to be cutting it close but should work. (assuming I get .3" higher, that still would give me 3.4 " clearance). I don't think there will be any problem with the extra width - from what I have seen.
BTW I have about 6k miles on the Westlakes now and they have held up fine, I'm thinking to swap them out before we take a longer trip in the fall just as a precaution. I keep them properly inflated, use a TPMS and I try to be careful with the sidewalls.