As you can see from my signature, I have a 2021 2500RL. Towing with a 2019 Sierra Denali 1500 with max tow package. Using a Curt TruTrack 1500K WDH hitch, with Air Bags installed on the truck. This truck has the 6.2L engine with 10 speed transmission. MPG is usually 8.5-9.5 using premium depending on weather, wind, and hills. Have traveled from Chicago area around Lake Superior, and recently down to Travelers Rest in North Carolina. The truck handles these trips without any problems. While I have not weighed at a CAT scale and “done the math”, in tow mode, with about 30# in the air bags, I have had no issues with semi’s, hills/mountains, rain, wind, etc. While having the hitch properly adjusted (it took me 3 years to get it properly set-and not by the dealer) is a must. The truck is a champ.
However, if I was full timing, heading through the Rockies, or going to Alaska, I would definitely look at a 3/4 ton truck. For my 3-4 trips a year, mostly in the Midwest, the half ton (mine is at the upper end of most half tons) works well for my usage.
Hope this info helps in your decision making. The 2500RL is a nice couples camper. Plenty of room yet relatively simple systems. Very happy with ours.
Happy camping,
MJG