Everyone has different circumstances. My wife works in the corporate world with fairly restrictive time off polices. I have a bit more flexibility owning my own business but for us everyday traveling is 1 less day on vacation. So I'm pushing as hard as possible. Heck, sometimes I'll drive out to our destination and she'll fly out to meet me to maximize our time.
I have no issues driving long hours. Pop in an audiobook and go. On a long trip 10 hours is probably average. I've gone as long as 16. I'll do as much as possible over night when the traffic is much lower. Less stress and slow downs and I prefer night driving.
We stop every 3-4 hours for fuel and don't rush the stop. Fill up, get something to eat, take the dog for a walk, and stretch out and relax for 15/20 min.
Last trip coming back from Charleston on my own I did it a bit differently, about 1100 miles after going around the closures in TN. I stopped twice but only for about a 2/3 hour nap at rest areas.
